Gold-Catalyzed Synthesis of Oxetan-3-ones from Propargylic Alcohols
نویسندگان
چکیده
منابع مشابه
Copper-catalyzed tandem annulation/arylation for the synthesis of diindolylmethanes from propargylic alcohols.
Various highly substituted 2,3'-diindolylmethane heterocycles were prepared from propargylic alcohols and indole nucleophiles via a transition metal-catalyzed tandem indole annulation/arylation reaction for the first time. Among the metal catalysts we examined, the most economical copper(I) catalyst provided the highest efficiency. The indole nucleophiles could also be replaced by other electro...
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The regioselective conversion of propargylic alcohols into previously unreported α,α-diiodo-β-hydroxyketones was achieved by treatment with N-iodosuccinimide in the presence of a gold catalyst. The corresponding α,α-dichloro-β-hydroxyketones were obtained by treatment with trichloroisocyanuric acid in the absence of a catalyst. The latter reaction can be extended to other alkynols. These transf...
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15 صفحه اولIron-catalyzed carbometalation of propargylic and homopropargylic alcohols.
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2-Substituted azetidin-3-ones can be prepared in good yields and enantioselectivities (up to 85% ee) by a one-pot procedure involving the metalation of the SAMP/RAMP hydrazones of N-Boc-azetidin-3-one, reaction with a wide range of electrophiles, including alkyl, allyl, and benzyl halides and carbonyl compounds, followed by hydrolysis using oxalic acid.
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ژورنال
عنوان ژورنال: Synfacts
سال: 2010
ISSN: 1861-1958,1861-194X
DOI: 10.1055/s-0030-1258618